Assessment of executive functions as a measure of impairments in everyday functioning in persons with HIV.

Persons with HIV can often present cognitive disorders such as those related to executive functioning, which could affect the daily life activities. The present study was designed to explore the predictive relationship between executive functions according to Miyake's model and the basic and instrumental skills of everyday functioning in a group of persons with HIV (PWH). Participants were recruited from outpatient treatment Hospital and assessed using a neuropsychological battery, a modified version of the Lawton and Brody basic and instrumental activities of daily life (ADL) scale and the Hospital Anxiety and Depression Scale (HADS). The results showed a low score in the executive function and significant relationship between executive functioning and the instrumental skills of the patients, with set-shifting being one of the most powerful predictors. The processes of executive functioning, particularly set-shifting, are related to the level of functioning in the skills required for independent living in the community, but not the skills of independent living in the home. This study seems to suggest the utility of assessing executive functions as a preventive measure for the development of dependencies in normal daily instrumental skills and as the focus of interdisciplinary interventions.

Objective memory as an indicator of functional impairment in native Spanish-speaking patients with HIV infection.

Objective memory is one of the most affected cognitive areas in patients with HIV and perhaps one of the best predictors of daily functioning problems. Its relationship with biological markers, mood symptoms, and cognitive complaint is unclear and has received little attention in native Spanish-speakers. The goal of this study is to explore the relationships between the above-mentioned variables and their prediction of objective memory performance in native Spanish-speakers. HIV-related biological markers, mood symptoms, cognitive complaint, and objective memory were assessed in a sample native Spanish-speaking HIV patient with possible cognitive impairment. The results revealed deficit in short- and long-term memory while recognition was retained. Hierarchical regression analysis showed that the combination of independent variables significantly predicted performance in recognition, indicating that the pattern of impairment in short- and long-term memory is related to a difficulty to learn new information discriminately. The non-prediction of short- and long-term memory performance may be related to the inability to estimate the deficit in objective memory. These results show the need to perform specific interventions in mnesic processes, in view of the relation between this cognitive process and patients' daily functioning.

Not All Differences between Patients with Schizophrenia and Healthy Subjects Are Pathological: Performance on the Conners' Continuous Performance Test.

OBJECTIVE: This study analyzed attentional performance in patients with schizophrenia during a continuous performance task requiring a high response rate. METHOD: The Conners' Continuous Performance Test-II (CPT-II) was administered to 64 patients with schizophrenia and 64 healthy comparison subjects. A cross-sectional design was used in order to allow analysis of the means between patients and healthy subjects. Differences in performance were assessed for significance using ANCOVA. Percentiles were also analyzed in order to determine whether a participant showed normal or pathological performance. Pearson's correlation was used to detect possible relationships between attentional performance and psychopathology. RESULTS: Of the 12 CPT-II measures, response style and slowing of reaction time (RT) between targets increased to similar extents between patients and healthy comparison subjects. Patients performed significantly less well than non-patient group on all other measures. Nevertheless, patient's performance on four of these measures remained within the normal range, and patient's performance on the remaining measures qualified as pathological only in the case of variability in hit RT. No significant correlations between attention performance and symptoms were found. CONCLUSIONS: These results suggest that although patients may show lower attentional functioning than non-patients on tasks requiring a high response rate, their attentional performance remains within the normal range on most dimensions.